Mood, Mental Wellbeing & Liver Support

Orthoplex White SAMe 400mg 30 Caps

By Orthoplex / BioConcepts
$92.95
High-strength Adonat® SAMe providing 400mg per tablet with activated vitamin B6, riboflavin and zinc to support emotional and general mental wellbeing, nervous-system health, healthy liver function and natural liver detoxification processes.
400mg SAMe
Emotional Wellbeing
Mental Wellbeing
Liver Support
Nervous System
Vegan
Always read the label and follow the directions for use.
Curated Wellness
Fast Dispatch
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Why you’ll love it
  • Provides 400mg SAMe per tablet
  • Uses patented Swiss Adonat®
  • Helps support emotional wellbeing
  • Supports general mental wellbeing
  • Supports healthy nervous-system function
  • Supports healthy liver function
  • Maintains natural liver detoxification processes
  • Includes activated pyridoxal-5-phosphate (P5P)
  • Provides riboflavin and zinc
  • Vegan and vegetarian friendly
  • Gluten, dairy and soy-protein free
  • Refrigerated formula with short-term room-temperature transit stability
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Orthoplex White SAMe 400mg 30 Caps

Key Benefits

A clear look at what this product is designed to support.

Orthoplex SAMe 400mg combines high-strength patented Adonat® SAMe with activated B6, riboflavin and zinc to provide practitioner-guided support for emotional wellbeing, mental wellbeing, nervous-system health and healthy liver detoxification.

Emotional Wellbeing

SAMe helps support healthy emotional balance and emotional wellbeing as part of everyday mental health support.

Mental Wellbeing

The high-strength SAMe formula supports general mental wellbeing and healthy nervous-system function.

Healthy Liver Function

SAMe provides nutritional support for healthy liver function as part of the body's normal metabolic processes.

Natural Liver Detoxification

Supports the body's natural liver detoxification processes without using aggressive detoxification claims.

Why it works

Ingredient Spotlight

A closer look at the formula.

Orthoplex SAMe 400mg combines patented Adonat® SAMe with activated vitamin B6, riboflavin and zinc in a refrigerated practitioner formula.

Adonat® SAMe

Adonat® SAMe

Each tablet provides 800mg S-adenosylmethionine disulfate tosylate, equivalent to 400mg active S-adenosylmethionine (SAMe).

Activated Vitamin B6

Activated Vitamin B6

Provides 25.08mg pyridoxal-5-phosphate monohydrate, equivalent to 16mg pyridoxine per tablet.

Riboflavin + Zinc

Riboflavin + Zinc

Each tablet provides 10mg riboflavin plus 5mg elemental zinc from zinc amino acid chelate to complement the SAMe formula.

Product Information

Everything you need to know

Orthoplex SAMe 400mg is a refrigerated practitioner formula containing high-strength patented Adonat® SAMe with activated vitamin B6, riboflavin and zinc for emotional, mental, nervous-system and liver support.

400mg SAMe per tablet
Patented Adonat® SAMe
Activated B6 + B2 + zinc
1 tablet twice daily
“High-strength SAMe support for emotional wellbeing, nervous-system health and natural liver function.”
Key Ingredients ⌄

Each tablet contains:

  • (S)-S-Adenosylmethionine disulfate tosylate (Adonat®) — 800mg
  • Equivalent S-Adenosylmethionine (SAMe) — 400mg
  • Pyridoxal 5-phosphate monohydrate — 25.08mg
  • Equivalent Pyridoxine (Vitamin B6) — 16mg
  • Riboflavin (Vitamin B2) — 10mg
  • Zinc amino acid chelate — 25mg
  • Equivalent Zinc — 5mg
How to Take ⌄

Adults: Take 1 tablet twice daily, or as recommended by your healthcare professional.

This is a large tablet. Swallow with a full glass of water.

Warnings ⌄
  • Large tablet — swallow with a full glass of water.
  • Contains vitamin B6.
  • Stop taking this product and consult your healthcare practitioner promptly if you experience tingling, burning or numbness.
  • People using prescription antidepressants should not use this product unless under healthcare-practitioner supervision.
  • People with bipolar depression should not use this product unless under healthcare-practitioner supervision.
  • Vitamin, mineral and nutritional supplements should not replace a balanced diet.
  • Always read the label and follow the directions for use.
  • Refrigerate at 2°C–8°C.
  • Do not freeze.
Allergens & Dietary Information ⌄

Suitable for:

  • Vegan diets
  • Vegetarian diets

BioConcepts lists the current product as:

  • Gluten free
  • Dairy free
  • Soy-protein free
  • Sulfites free

Important storage requirement:

  • Refrigerate at 2°C–8°C
  • Do not freeze
  • Short-term ambient transit up to approximately 7 days is accommodated by the formulation
How to Use

Simple and straightforward

Orthoplex SAMe 400mg follows a twice-daily practitioner-guided routine and requires refrigerated storage to maintain the intended SAMe potency.

Always follow the label and practitioner guidance.
1

Take One Tablet

Take 1 SAMe 400mg tablet per dose.

›
2

Repeat Twice Daily

Take one tablet twice daily, or follow the individual directions provided by your healthcare professional.

›
3

Keep Refrigerated

Store between 2°C and 8°C and do not freeze. Swallow each large tablet with a full glass of water.

›
Practitioner Guidance

A practitioner-led approach

“Orthoplex SAMe 400mg combines high-strength patented Adonat® SAMe with activated vitamin B6, riboflavin and zinc for practitioner-guided support of emotional wellbeing, nervous-system health and healthy liver function.”

Victoria O'Sullivan
Victoria O'Sullivan Naturopath

400mg Adonat® SAMe

Each tablet delivers 400mg active SAMe from the patented Swiss Adonat® form of S-adenosylmethionine.

Mental + Nervous System Support

SAMe, activated B6, riboflavin and zinc provide complementary nutritional support for emotional and general mental wellbeing and healthy nervous-system function.

Liver Support

The formula supports healthy liver function and helps maintain the body's natural liver detoxification processes.

What Our Customers Say

Real reviews. Real experiences.

Read experiences shared by customers who have used products from our wellness range.

★★★★★

“My practitioner recommended SAMe 400mg as part of my wellbeing plan. I appreciate that it uses the Adonat form and clearly lists the active SAMe amount in each tablet.”

Genevieve R.
✓ Verified Purchase
★★★★★

“I wanted a practitioner SAMe product with additional nutritional cofactors rather than SAMe alone. The tablets are quite large, but taking them with a full glass of water works well for me.”

Marlene T.
✓ Verified Purchase
★★★★★

“A very clearly formulated practitioner product. I like that the SAMe, activated B6, riboflavin and zinc amounts are all stated and the storage instructions are straightforward.”

Claudia H.
✓ Verified Purchase
Frequently Asked Questions

Got a question?

Helpful answers about this product, how to use it and what to know before purchasing.

What is Orthoplex SAMe 400mg designed to support?⌄

Orthoplex SAMe 400mg is formulated to support emotional and general mental wellbeing, healthy nervous-system and liver function, and the body's natural liver detoxification processes.

How much SAMe is in each tablet?⌄

Each tablet contains 800mg S-adenosylmethionine disulfate tosylate in the patented Adonat® form, providing 400mg active S-adenosylmethionine (SAMe).

How do I take Orthoplex SAMe 400mg?⌄

Adults take 1 tablet twice daily, or as directed by their healthcare professional. The tablets are large and should be swallowed with a full glass of water.

Does SAMe 400mg need refrigeration?⌄

Yes. Store Orthoplex SAMe 400mg refrigerated between 2°C and 8°C and do not freeze. The formulation is designed to tolerate up to approximately 7 days of ambient-temperature transit, but refrigeration remains the normal storage condition.

Can I take SAMe 400mg with antidepressants?⌄

Orthoplex states that people using prescription antidepressants, or people with bipolar depression, should not use SAMe 400mg unless under the supervision of a healthcare practitioner.