Stress, Energy & Neuroendocrine Support

HPA Essentials 60 Tabs

By Metagenics
$49.95
High-strength nutritional formula with vitamin B5, vitamin C and activated B vitamins to support a healthy response to stress, neuroendocrine function, neurotransmitter synthesis and healthy energy production.
Healthy Stress Response
Energy Support
Neuroendocrine Function
Activated B Vitamins
450mg Vitamin C
Vegan
Always read the label and follow the directions for use.
Curated Wellness
Fast Dispatch
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Why you’ll love it
  • Supports a healthy response to stress
  • Supports healthy neuroendocrine function
  • Provides 300mg vitamin B5 per tablet
  • Provides 450mg vitamin C per tablet
  • Supports healthy energy production
  • Helps support neurotransmitter synthesis
  • Contains activated P5P vitamin B6
  • Contains activated riboflavin-5-phosphate
  • Provides active 5-MTHF folate
  • Includes mecobalamin B12
  • Vegan friendly
  • Gluten, dairy and soy-protein free
  • Simple 1 tablet twice daily with food routine
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Clear Product Information

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HPA Essentials 60 Tabs

Key Benefits

A clear look at what this product is designed to support.

HPA Essentials combines high-strength vitamin B5 and vitamin C with activated B vitamins to provide practitioner-guided nutritional support for healthy stress adaptation, energy production, neuroendocrine function and neurotransmitter metabolism.

Healthy Stress Response

Vitamin B5, vitamin C and complementary B-group nutrients support the body's normal physiological response to everyday stress.

Neuroendocrine Support

High-dose vitamin B5 and vitamin C provide nutritional support for healthy neuroendocrine function, linking nervous-system and hormonal signalling.

Healthy Energy Levels

B-group vitamins support normal cellular energy production and help maintain healthy energy levels during demanding periods.

Neurotransmitter Support

Activated B vitamins assist normal metabolism and synthesis of neurotransmitters involved in healthy nervous-system communication.

Why it works

Ingredient Spotlight

A closer look at the formula.

HPA Essentials combines high-dose stress-support nutrients with activated B vitamins, active folate and methylated B12 for broad nutritional support of energy and neuroendocrine pathways.

Vitamin B5 + Vitamin C

Vitamin B5 + Vitamin C

Each tablet provides 300mg calcium pantothenate plus 450mg vitamin C to support energy production, healthy stress response and neuroendocrine function.

Activated B Vitamins

Activated B Vitamins

Includes P5P vitamin B6 and riboflavin sodium phosphate alongside B1 and B3 for energy and neurotransmitter metabolism.

5-MTHF + Methyl B12

5-MTHF + Methyl B12

Provides 200mcg active 5-MTHF folate and 200mcg mecobalamin vitamin B12 to support normal methylation and nervous-system nutrient pathways.

Product Information

Everything you need to know

Metagenics HPA Essentials is a practitioner nutritional formula combining high-dose vitamin B5 and vitamin C with activated B vitamins, active folate, methylated B12, biotin and citrus bioflavonoids to support stress adaptation, neuroendocrine function and healthy energy production.

300mg vitamin B5 per tablet
450mg vitamin C per tablet
Activated B vitamins + 5-MTHF
1 tablet twice daily with food
“Targeted nutritional support for healthy stress response, neuroendocrine function and everyday energy.”
Key Ingredients ⌄

Each tablet contains:

  • Calcium ascorbate dihydrate — 545mg
  • Equivalent Ascorbic Acid (Vitamin C) — 450mg
  • Calcium pantothenate (Vitamin B5) — 300mg
  • Citrus bioflavonoids extract — 50mg
  • Thiamine hydrochloride (Vitamin B1) — 50mg
  • Nicotinamide (Vitamin B3) — 50mg
  • Pyridoxal-5-phosphate monohydrate — 50mg
  • Equivalent Pyridoxine — approximately 32.5mg
  • Riboflavin sodium phosphate (activated B2) — 20mg
  • Biotin — 500mcg
  • Levomefolate calcium — 217mcg
  • Equivalent Levomefolic Acid (5-MTHF) — 200mcg
  • Mecobalamin (Vitamin B12) — 200mcg
How to Take ⌄

Adults: Take 1 tablet twice daily with food, or as directed by your healthcare professional.

Warnings ⌄
  • Contains vitamin B6.
  • Stop taking this product and see your healthcare practitioner promptly if you experience tingling, burning or numbness.
  • Vitamin supplements should not replace a balanced diet.
  • If symptoms persist, consult your healthcare professional.
  • If taking prescription medicines, discuss supplementation with your healthcare practitioner.
  • Always read the label and follow the directions for use.
  • Store below 30°C.
  • Keep out of reach of children.
Allergens & Dietary Information ⌄

Suitable for:

  • Vegan diets
  • Vegetarian diets

Free from:

  • Animal products
  • Corn
  • Dairy protein
  • Lactose
  • Eggs
  • Gluten
  • Wheat
  • Nuts
  • Yeast
  • Soy protein
  • Starches
  • Salt
  • Artificial colours
  • Artificial flavours
  • Artificial preservatives
How to Use

Simple and straightforward

HPA Essentials follows a simple twice-daily routine, providing activated B vitamins and high-dose nutritional cofactors throughout the day for energy, stress-response and neuroendocrine support.

Always follow the label and practitioner guidance.
1

Take One Tablet

Take 1 HPA Essentials tablet per dose.

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2

Take With Food

Take the tablet with food to fit comfortably into your morning and later-day routine.

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3

Repeat Twice Daily

Take 1 tablet twice daily, or follow your healthcare practitioner's individual recommendation.

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Practitioner Guidance

A practitioner-led approach

“HPA Essentials combines high-dose vitamin B5 and vitamin C with activated B vitamins and methylation nutrients in a focused formula for practitioner-guided stress, energy and neuroendocrine support.”

Victoria O'Sullivan
Victoria O'Sullivan Naturopath

High-Dose B5 + Vitamin C

Each tablet provides 300mg vitamin B5 and 450mg vitamin C to support energy production, healthy stress response and neuroendocrine function.

Activated B Nutrients

P5P, activated riboflavin, 5-MTHF and mecobalamin provide metabolically active nutrient forms for nervous-system and neurotransmitter support.

Energy + Neurotransmitter Support

The broad B-vitamin combination supports healthy energy production and normal synthesis and metabolism of neurotransmitters.

What Our Customers Say

Real reviews. Real experiences.

Read experiences shared by customers who have used products from our wellness range.

★★★★★

“My practitioner recommended HPA Essentials during a particularly demanding period. I like that it combines the activated B vitamins with high-dose B5 and vitamin C in one formula.”

Sophie R.
✓ Verified Purchase
★★★★★

“I wanted a practitioner B-vitamin formula focused on both stress and energy support. Taking one tablet with breakfast and another later in the day has been easy to remember.”

Katrina L.
✓ Verified Purchase
★★★★★

“A comprehensive nutritional formula with clearly listed active forms of folate, B6 and B12. I appreciate that one bottle provides a full month at the standard dose.”

Marielle C.
✓ Verified Purchase
Frequently Asked Questions

Got a question?

Helpful answers about this product, how to use it and what to know before purchasing.

What is Metagenics HPA Essentials designed to support?⌄

HPA Essentials is formulated to support healthy energy levels, a healthy response to stress and neuroendocrine function. Its activated B vitamins also assist normal neurotransmitter metabolism and synthesis.

What does HPA mean?⌄

HPA commonly refers to the hypothalamic-pituitary-adrenal axis, part of the body's neuroendocrine stress-response system. Metagenics positions HPA Essentials around supporting healthy neuroendocrine function and stress adaptation rather than treating an adrenal disorder.

How do I take HPA Essentials?⌄

Adults take 1 tablet twice daily with food, or follow the individual directions provided by their healthcare professional. A 60-tablet bottle provides approximately 30 days at the standard dose.

Does HPA Essentials contain activated B vitamins?⌄

Yes. The formula includes pyridoxal-5-phosphate, riboflavin sodium phosphate, active 5-MTHF folate and mecobalamin vitamin B12, together with B1, B3, B5 and biotin.

Is HPA Essentials vegan and gluten free?⌄

Yes. Metagenics lists HPA Essentials as free from animal products, gluten, wheat, dairy protein, lactose, eggs, nuts and soy protein, making it suitable for vegan and vegetarian diets.