Methyl Donor Support
Trimethylglycine provides methyl groups used in normal one-carbon metabolism and the methionine cycle
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Orthoplex White TMG 100g
Key Benefits
A clear look at what this product is designed to support.
TMG is a naturally occurring methyl donor used by practitioners in individually compounded formulas where targeted trimethylglycine supplementation is considered appropriate.
Homocysteine Metabolism
Betaine participates in the BHMT pathway, donating a methyl group for the normal remethylation of homocysteine to methionine.
Cellular Osmolyte Function
Betaine also functions naturally as an organic osmolyte, helping cells maintain normal volume and protein stability under osmotic stress.
Pure Compounding Ingredient
Contains pure trimethylglycine with no added excipients, allowing practitioners to tailor the amount within individually prepared formulations.
Why it works
Ingredient Spotlight
A closer look at the formula.
Orthoplex TMG contains one ingredient only: pure trimethylglycine, also known as betaine anhydrous, supplied as a practitioner compounding powder.
Trimethylglycine (TMG)
One level included scoop contains 4.9g trimethylglycine, also known as betaine. No additional active ingredients are included.
Methylation Pathway
TMG acts as a methyl donor through betaine-homocysteine methyltransferase (BHMT), contributing to the conversion of homocysteine into methionine.
Zero Added Excipients
BioConcepts lists no manufacturing or incidental excipients, making this a straightforward single-ingredient powder for customised practitioner compounding.
Product Information
Everything you need to know
Orthoplex TMG is a pure trimethylglycine oral powder supplied specifically for extemporaneous compounding by suitably qualified healthcare practitioners. It provides a flexible methyl donor ingredient for individually designed practitioner formulations.
Pure trimethylglycine powder
4.9g per level scoop
No added excipients
Practitioner compounding only
“A pure single-ingredient TMG powder for individually tailored practitioner compounding.”
Key Ingredients ⌄
How to Take ⌄
Warnings ⌄
Allergens & Dietary Information ⌄
How to Use
Simple and straightforward
Orthoplex TMG is intended for individually prescribed extemporaneous compounding, so the amount and preparation method should be determined by a suitably qualified healthcare practitioner.
Always follow the label and practitioner guidance.
Follow Your Practitioner Formula
Use only the amount of TMG specified in the personalised formulation prepared or prescribed by your healthcare practitioner.
Measure Accurately
Use the included scoop as a measuring reference—one level scoop contains 4.9g TMG—but do not assume a full scoop is your prescribed dose.
Store Carefully
Keep the powder tightly closed below 30°C in a cool, dry place away from direct sunlight, and follow your practitioner's instructions for the finished compound.
Practitioner Guidance
A practitioner-led approach
“TMG provides a pure, excipient-free trimethylglycine source for practitioners requiring flexible methyl-donor supplementation within individually designed extemporaneous formulations.”
Victoria O'Sullivan
Naturopath
Pure Single Ingredient
Contains trimethylglycine only, with no manufacturing excipients listed by BioConcepts.
Methyl Donor Biochemistry
Betaine donates a methyl group through BHMT during normal homocysteine-to-methionine remethylation and one-carbon metabolism.
Flexible Compounding Format
The 100g oral powder allows the practitioner to individualise the amount of TMG rather than relying on a fixed-dose finished supplement.
What Our Customers Say
Real reviews. Real experiences.
Read experiences shared by customers who have used products from our wellness range.
★★★★★
“My practitioner included TMG in a personalised powder formula for me. I appreciate that the Orthoplex product contains only trimethylglycine with no added excipients.”
Loretta M.✓ Verified Purchase
★★★★★
“I use this only according to my practitioner's compounding instructions. The single-ingredient powder makes it straightforward for my naturopath to tailor the amount within my plan.”
Nadine P.✓ Verified Purchase
★★★★★
“I like knowing exactly what is in the product—just TMG and no excipients. My practitioner gives me the specific amount and preparation instructions to follow.”
Estelle R.✓ Verified Purchase
Frequently Asked Questions
Got a question?
Helpful answers about this product, how to use it and what to know before purchasing.
What is TMG?⌄
What role does TMG play in methylation?⌄
How much TMG is in one scoop?⌄
Can I take Orthoplex TMG directly as a normal supplement?⌄
Is Orthoplex TMG vegan and gluten free?⌄
Orthoplex White TMG 100g
